Canine Infarction Model

Comparison of human ventricular activation with a canine model in chronic myocardial infarction.

Ventricular activation was studied in 20 patients with ischemic heart disease at the time of surgery for myocardial revascularization. Because most of the activation studies in man were limited to recording of epicardial potentials, a canine model of chronic infarction was also studied. Preand postinfarction data were recorded in dogs and correlated with the anatomy of the lesions. Epicardial Q...

Therapeutic effect of nerve growth factor on canine cerebral infarction evaluated by MRI

To explore therapeutic effect of nerve growth factor (NGF) on cerebral infarction by establishing canine middle cerebral artery occlusion (MCAO) infarct model. The magnetic resonance imaging (MRI) technology was used to study effects of NGF on cerebral infarction, and the results of MRI indexes (such as diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI)) were compared with th...

Imaging of post-infarction myocardial inflammation with hybrid FDG PET/MR: feasibilty and preliminary findings in a canine model

Background An understanding of inflammation following myocardial infarction may be of importance in the development of novel therapeutics to limit the development of heart failure following myocardial injury. However, the quantification of inflammation in this setting continues to be challenging. Hybrid FDG PET/MR may offer a non-invasive in vivo solution through intrinsic registration of these...

Effect of Cardiac Stem Cells on Left Ventricular Remodeling in a Canine Model of Chronic Myocardial Infarction Welt et al: Cardiac Stem Cells in Chronic Myocardial Infarction

Dose dependency of the post-insult protective effect of pentobarbital in the canine experimental stroke model.

In a canine stroke model, dose dependent protection by postocclusion pentobarbital was suggested from 10--40 mg/kg. In 28 dogs investigated (10 from a previous study) a distinct, significant reduction in right cerebral hemisphere infarction occurred in animals given 15--20 mg/kg pentobarbital intramuscularly 1 hour postocclusion. Increased dosages did not alter statistically the infarct size an...

Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage

Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a charac...